Identification of differentially expressed genes regulated by methylation in colon cancer based on bioinformatics analysis.

ABSTRACT:

Background

DNA methylation, acknowledged as a key modification in the field of epigenetics, regulates gene expression at the transcriptional level. Aberrant methylation in DNA regulatory regions could upregulate oncogenes and downregulate tumor suppressor genes without changing the sequences. However, studies of methylation in the control of gene expression are still inadequate. In the present research, we performed bioinformatics analysis to clarify the function of methylation and supply candidate methylation-related biomarkers and drivers for colon cancer.

Aim

To identify and analyze methylation-regulated differentially expressed genes (MeDEGs) in colon cancer by bioinformatics analysis.

Methods

We downloaded RNA expression profiles, Illumina Human Methylation 450K

SUBMITTER: Liang Y 

PROVIDER: S-EPMC6639549 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature