Synthesis and synergistic studies of isatin based mixed ligand complexes as potential antifungal therapeutic agents.

ABSTRACT: Metal based drugs are important class of chemotherapeutic agents that have the potential to circumvent drug resistance. Increasing drug resistance, treatment failures and limited treatment options necessitates the development of new therapeutic drugs with different mechanisms of action. Towards this direction, we synthesized a series of isatin based mixed ligand complexes of [Cu(dbm)LClH₂O] (mlc1), [Co(dbm)LCl₂]^‒ (mlc2) and [Ni(dbm)LClH₂O] (mlc3) and evaluated their antifungal activity alone and in combination with fluconazole (FLC) against seven different Candida albicans isolates. The insight mechanism of antifungal action was revealed by studying apoptosis via terminal deoxynucleotidyl transferase dUTP nick-end labe

SUBMITTER: Dar OA 

PROVIDER: S-EPMC6639752 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature