Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression.

ABSTRACT:

Background

Increasing evidence has revealed a close relationship between non-coding RNAs and cancer progression. Circular RNAs (circRNAs), a recently identified new member of non-coding RNAs, are demonstrated to participate in diverse biological processes, such as development, homeostatic maintenance and pathological responses. The functions of circRNAs in cancer have drawn wide attention recently. Until now, the expression patterns and roles of circRNAs in hepatocellular carcinoma (HCC) have remained largely unknown.

Methods

Bioinformatics method was used to screen differentially expressed novel circRNAs in HCC. Northern blotting, qRT-PCR, in situ hybridization (ISH) and RNA-FISH were utilized to analyzed the expression of circRHOT1 in HCC tisues.CCK8, colony formation, EdU

SUBMITTER: Wang L 

PROVIDER: S-EPMC6639939 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature