HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8⁺ T-cell Tumor Infiltration in OPSCC.

ABSTRACT: Presence of tumor-infiltrating lymphocytes (TIL) predicts survival in many cancer types. In HPV-driven cancers, cervical and oropharyngeal squamous cell carcinomas (CSCC and OPSCC, respectively), numbers of infiltrating T cells, particularly CD8⁺ T cells, and presentation of HPV E6/E7 epitopes are associated with improved prognosis. Endoplasmic reticulum aminopeptidase 1 (ERAP1) regulates the presented peptide repertoire, trimming peptide precursors prior to MHC I loading. ERAP1 is polymorphic, and allotypic variation of ERAP1 enzyme activity has an impact on the presented peptide repertoire. Individual SNPs are associated with incidence and outcome in a number of diseases, including CSCC. Here, we highlight the requirement for ERAP1 in the generation of HPV E6/E7 epitopes and s

SUBMITTER: Reeves E 

PROVIDER: S-EPMC6640044 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature