The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Bercovici N
PROVIDER: S-EPMC6640155 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer.
Bercovici Nadège N Guérin Marion V MV Trautmann Alain A Donnadieu Emmanuel E
Frontiers in immunology 20190712
It is well established that tumor-associated macrophages (TAM) found in most advanced tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating lymphocytes (TIL), and a number of mechanisms have been described including a trapping in the stroma, impeding TIL to reach malignant cells. Based on these results, a number of therapeutic approaches have been designed to deplete TAM. However, during tumor regression induced by immunotherapeutic treatments, recent stud ...[more]
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