Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 β cells.

ABSTRACT: Growing evidence suggests that exposure to environmental contaminants contributes to the current diabetes epidemic. Inorganic arsenic (iAs), a drinking water and food contaminant, is one of the most widespread environmental diabetogens according to epidemiological studies. Several schemes have been proposed to explain the diabetogenic effects of iAs exposure; however, the exact mechanism remains unknown. We have shown that in vitro exposure to low concentrations of arsenite (iAs^III) or its trivalent methylated metabolites, methylarsonite (MAs^III) and dimethylarsinite (DMAs^III), inhibits glucose-stimulated insulin secretion (GSIS) from isolated pancreatic islets, with little effect on insulin transcription or total insulin content. The goal of this study was

SUBMITTER: Dover EN 

PROVIDER: S-EPMC6640649 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature