Controlling Confounding in a Study of Oral Anticoagulants: Comparing Disease Risk Scores Developed Using Different Follow-Up Approaches.

ABSTRACT:

Purpose

Little is known about how disease risk score (DRS) development should proceed under different pharmacoepidemiologic follow-up strategies. In an analysis of dabigatran vs. warfarin and risk of major bleeding, we compared the results of DRS adjustment when models were developed under "intention-to-treat" (ITT) and "as-treated" (AT) approaches.

Methods

We assessed DRS model discrimination, calibration, and ability to induce prognostic balance via the "dry run analysis". AT treatment effects stratified on each DRS were compared with each other and with a propensity score (PS) stratified reference estimate. Bootstrap resampling of the historical cohort at 10 percent-90 percent sample size was performed to assess the impact of sample size on DRS estimation.

Results

SUBMITTER: Bohn J 

PROVIDER: S-EPMC6640656 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature