Design Principles for Bispecific IgGs, Opportunities and Pitfalls of Artificial Disulfide Bonds.

ABSTRACT: Bispecific antibodies (bsAbs) are antibodies with two binding sites directed at different antigens, enabling therapeutic strategies not achievable with conventional monoclonal antibodies (mAbs). Since bispecific antibodies are regarded as promising therapeutic agents, many different bispecific design modalities have been evaluated, but as many of them are small recombinant fragments, their utility could be limited. For some therapeutic applications, full-size IgGs may be the optimal format. Two challenges should be met to make bispecific IgGs; one is that each heavy chain will only pair with the heavy chain of the second specificity and that homodimerization be prevented. The second is that each heavy chain will only pair with the light chain of its own specificity and not with the light c

SUBMITTER: Vaks L 

PROVIDER: S-EPMC6640675 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature