Nanobody Engineering: Toward Next Generation Immunotherapies and Immunoimaging of Cancer.

ABSTRACT: In the last decade, cancer immunotherapies have produced impressive therapeutic results. However, the potency of immunotherapy is tightly linked to immune cell infiltration within the tumor and varies from patient to patient. Thus, it is becoming increasingly important to monitor and modulate the tumor immune infiltrate for an efficient diagnosis and therapy. Various bispecific approaches are being developed to favor immune cell infiltration through specific tumor targeting. The discovery of antibodies devoid of light chains in camelids has spurred the development of single domain antibodies (also called VHH or nanobody), allowing for an increased diversity of multispecific and/or multivalent formats of relatively small sizes endowed with high tissue penetration. The small size of nanobodi

SUBMITTER: Chanier T 

PROVIDER: S-EPMC6640690 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature