Glycopolypeptide-Grafted Bioactive Polyionic Complex Vesicles (PICsomes) and Their Specific Polyvalent Interactions.

ABSTRACT: Glycopolypeptide-based self-assembled nano-/microstructures with surface-tethered carbohydrates are excellent mimics of glycoproteins on the cell surface. To expand the broad repertoire of glycopolypeptide-based supramolecular soft structures such as polymersomes formed via self-assembly of amphiphilic polymers, we have developed a new class of polyionic complex vesicles (PICsomes) with glycopolypeptides grafted on the external surface. Oppositely charged hydrophilic block copolymers of glycopolypeptide₂₀-b-poly-l-lysine₁₀₀ and PEG_2k-b-poly-l-glutamate₁₀₀ [PEG = poly(ethylene glycol)] were synthesized using a combination of ring-opening polymerization of N-carboxyanhydrides and "click" chemistry. Under physiological condition

SUBMITTER: Pandey B 

PROVIDER: S-EPMC6640804 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature