Serum Protein-Resistant Behavior of Multisite-Bound Poly(ethylene glycol) Chains on Iron Oxide Surfaces.

ABSTRACT: Recent surveys have shown that the number of nanoparticle-based formulations actually used at a clinical level is significantly lower than that expected a decade ago. One reason for this is that the physicochemical properties of nanoparticles fall short for handling the complexity of biological environments and preventing nonspecific protein adsorption. In this study, we address the issue of the interactions of plasma proteins with polymer-coated surfaces. With this aim, we use a noncovalent grafting-to method to functionalize iron oxide sub-10 nm nanoparticles and iron oxide flat substrates and compare their protein responses. The functionalized copolymers consist of alternating poly(ethylene glycol) (PEG) chains and phosphonic acid grafted on the same backbone. Quartz crystal microbalanc

SUBMITTER: Giamblanco N 

PROVIDER: S-EPMC6640927 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature