Multi-scale modeling of the circadian modulation of learning and memory.

ABSTRACT: We propose a multi-scale model to explain the time-of-day effects on learning and memory. We specifically model the circadian variation of hippocampus (HC) dependent long-term potentiation (LTP), depression (LTD), and the fear conditioning paradigm in amygdala. The model we built has both Goodwin type circadian gene regulatory network (GRN) and the conductance model of Morris-Lecar (ML) type to explain the spontaneous firing patterns (SFR) in suprachiasmatic nucleus (SCN). In the conductance model, we also include N-Methyl-D-aspartic acid receptor (NMDAR) to study the circadian dependent changes in LTP/LTD in hippocampus and include both NMDAR and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) dynamics to explain the circadian modulation of fear conditioning paradigm

SUBMITTER: S S 

PROVIDER: S-EPMC6641212 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature