Revised Mechanism for a Ruthenium-Catalyzed Coupling of Aldehyde and Terminal Alkyne.

ABSTRACT: Ruthenium catalysts have been found to be of great use for many kinds of reactions. Understanding the details of the catalytic cycle allows to not only rationalize experimental results but also to improve upon reactions. Herein, we present a detailed computational study of a ruthenium-catalyzed coupling between a terminal alkyne and an aldehyde. The reaction under examination facilitates novel access to olefins with the concurrent loss of a single carbon as carbon monoxide. The reaction was first developed in 2009, but the tentative mechanism initially proposed was proven to be contradictory to some experimental data obtained since then. Using a combination of computational investigations and isotope-labeling experiments, several potential mechanisms have been studied. In contrast to the [

SUBMITTER: Tomberg A 

PROVIDER: S-EPMC6641445 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature