Selective serotonin reuptake inhibitors and risk of epilepsy after traumatic brain injury - A population based cohort study.

ABSTRACT:

Objective

Traumatic brain injury (TBI) is common and associated with a marked increased risk of developing epilepsy. Animal studies indicate that treatment with selective serotonin reuptake inhibitors (SSRIs) may increase the risk of epilepsy after TBI. The aim of this study was to investigate whether use of SSRIs modifies the risk of epilepsy after TBI.

Methods

This was a cohort study of 205,715 persons, who suffered a TBI in Denmark from 1996 to 2013. For each person with TBI, we matched 10 reference persons (N = 2,057,150) who were alive on the day of TBI and who had the same age and gender but had no history of TBI. We used a stratified Cox regression to calculate the relative risk of epilepsy after TBI for persons exposed to TBI, SSRI or both after adjustment for income

SUBMITTER: Christensen J 

PROVIDER: S-EPMC6641473 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature