A Small Molecule Inhibitor of Bruton's Tyrosine Kinase Involved in B-Cell Signaling.

ABSTRACT: Protein kinases are fundamental within almost all cellular signal transduction networks. Among these, Bruton's tyrosine kinase (Btk), which belongs to the Tec family of proteins, plays an imperative part in B-cell signaling. Owing to its role, Btk has been established as an important therapeutic target for a vast range of disorders related to B-cell development and function, such as the X-linked agammaglobulinemia, various B-cell malignancies, inflammation, and autoimmune diseases. Herein, using computer-based screening of a library of 20 million small molecules, we identified a small molecule capable of directly binding the Btk kinase domain. On the basis of this hit compound, we conducted a focused structure-similarity search to explore the effect of different chemical modifications on b

SUBMITTER: Ratzon E 

PROVIDER: S-EPMC6641755 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature