Umbilical cord blood-based gene signatures related to prenatal major depressive disorder.

ABSTRACT:

Background

Prenatal exposure to depression has been considered as a risk factor for adverse childhood, while it is accompanied by unknown molecular mechanisms. The aim of this study was to identify differentially expressed genes (DEGs) and associated biological processes between cord blood samples from neonates born to mothers who exposed to major depressive disorder (MDD) and healthy mothers.

Methods

The microarray data GSE114852 were downloaded to analyze the mRNA expression profiles of umbilical cord blood with 31 samples exposed to prenatal MDD and 62 samples with healthy mothers. Kyoto Encyclopedia of Genes and Genomes pathway and Gene ontology enrichment analyses were conducted to identify associated biochemical pathways and functional categories of the DEGs. The prote

SUBMITTER: Liu W 

PROVIDER: S-EPMC6641773 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature