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Catalyst-Free Cross-Dehydrogenative Coupling Strategy Using Air as an Oxidant: Synthesis of α-Aminophosphonates.

ABSTRACT: α-Aminophosphonates are synthesized by employing unfunctionalized starting materials using cross-dehydrogenative coupling strategy. This method does not require any catalyst and proceeds in the presence of open air as the only oxidant. Mechanistic studies revealed that the reaction is nucleophile dependent and specific to dialkyl phosphite and N-aryl tetrahydroisoquinoline derivatives.

SUBMITTER: Dhineshkumar J

PROVIDER: S-EPMC6641911 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Catalyst-Free Cross-Dehydrogenative Coupling Strategy Using Air as an Oxidant: Synthesis of α-Aminophosphonates.

Dhineshkumar Jayaraman J Samaddar Prasanjit P Prabhu Kandikere Ramaiah KR

ACS omega 20170823 8

α-Aminophosphonates are synthesized by employing unfunctionalized starting materials using cross-dehydrogenative coupling strategy. This method does not require any catalyst and proceeds in the presence of open air as the only oxidant. Mechanistic studies revealed that the reaction is nucleophile dependent and specific to dialkyl phosphite and N-aryl tetrahydroisoquinoline derivatives. ...[more]

PMID: 31457767

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