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I₂-Catalyzed Oxidative Cross-Coupling Reaction of Methyl Ketones and 2-(2-Aminophenyl) Benzimidazole: Facile Access to Benzimidazo[1,2-c]quinazoline.

ABSTRACT: A general and efficient iodine-catalyzed metal-free oxidative cross-coupling reaction of methyl ketones with 2-(1H-benzo[d]imidazol-2-yl)aniline has been established. This is a new synthetic strategy for the synthesis of benzimidazo[1,2-c]quinazoline derivatives involving C(sp³)-H oxidation, condensation, and cyclization processes.

SUBMITTER: Ambethkar S

PROVIDER: S-EPMC6641929 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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I2-Catalyzed Oxidative Cross-Coupling Reaction of Methyl Ketones and 2-(2-Aminophenyl) Benzimidazole: Facile Access to Benzimidazo[1,2-c]quinazoline.

Ambethkar Sethurajan S Kalaiselvi Mariappan M Ramamoorthy Jaganathan J Padmini Vediappen V

ACS omega 20180508 5

A general and efficient iodine-catalyzed metal-free oxidative cross-coupling reaction of methyl ketones with 2-(1H-benzo[d]imidazol-2-yl)aniline has been established. This is a new synthetic strategy for the synthesis of benzimidazo[1,2-c]quinazoline derivatives involving C(sp3)-H oxidation, condensation, and cyclization processes. ...[more]

PMID: 31458715

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