Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.

ABSTRACT: Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells and consequently the production of pathogenic autoantibodies. The main purpose of our work was to determine whether transitional B cells, as the most immature naïve B cell subset upstream of pathogenic B cells, display specific features compared to healthy non SLE subjects. Through extensive analysis of transitional B cells from untreated or low treated, mostly Caucasian, SLE patients, we demonstrated that transitional (T1 and T2) B cell frequencies were increased in SLE and positively correlated with disease activity. SLE transitional B cells displayed defects i

SUBMITTER: Dieudonne Y 

PROVIDER: S-EPMC6642027 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature