The landscape of novel and complementary targets for immunotherapy: an analysis of gene expression in the tumor microenvironment.

ABSTRACT: Background: Immunotherapies targeting immune checkpoint proteins CTLA-4, PD-1, and PD-L1 have saved lives, but these therapies have only been effective in some patients. Patients positive for expression of immune checkpoint proteins in the tumor microenvironment show better response to immune checkpoint inhibitors. Consequently, knowledge of which genes are consistently expressed in lymphocytes within the tumor microenvironment can convey potentially effective and complementary new immunotherapy targets. Results: We identified 54 genes that have higher co-expression with the pan T-cell marker CD3E than CTLA4 or PDCD1. In a dataset of 26 patients who received anti-PD-1 therapy, we observed that co-expression between CD3E and PDCD1 was higher

SUBMITTER: Gaffney SG 

PROVIDER: S-EPMC6642048 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature