Obesity in acute alcoholic hepatitis increases morbidity and mortality.

ABSTRACT:

Background

Alcohol and obesity synergise to increase the risk of liver-related mortality. We examined the influence of adiposity on clinical outcomes in alcoholic hepatitis (AH) and the underlying inflammatory crosstalk between adipose tissue (AT) and the liver.

Methods

A cohort of 233 patients with AH from the UK and USA provided data to analyse the effects of obesity in AH. Body mass index was corrected for the severity of ascites, termed cBMI. Inflammatory and metabolic profiling was undertaken by proteome analysis of human serum samples. The effect of alcohol on adipose tissue and CXCL11 expression was studied in 3 T3-derived adipocytes and in mice using the high-fat diet-plus-binge ethanol model.

Findings

Obesity was common amongst patients with AH, seen in 19% o

SUBMITTER: Parker R 

PROVIDER: S-EPMC6642069 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature