Biosynthetic homeostasis and resilience of the complement system in health and infectious disease.

ABSTRACT:

Background

The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. However, very little is known about steady state levels in children or its kinetics during infection.

Methods

With a newly developed multiplex mass spectrometry-based method we analyzed the levels of 32 complement proteins in healthy individuals and in a group of pediatric patients infected with bacterial or viral pathogens.

Findings

In plasma from young infants we found reduced levels of C4BP, ficolin-3, factor B, classical pathway components C1QA, C1QB, C1QC, C1R, an

SUBMITTER: Willems E 

PROVIDER: S-EPMC6642076 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature