The anti-aflatoxigenic mechanism of cinnamaldehyde in Aspergillus flavus.

ABSTRACT: Aflatoxin B₁ (AFB₁), the predominant and most carcinogenic naturally polyketide, is mainly produced by Aspergillus flavus and Aspergillus parasiticus. Cinnamaldehyde has been reported for inhibiting the growth and aflatoxin biosynthesis in A. flavus. But its molecular mechanism of action still remains largely ambiguous. Here, the anti-aflatoxigenic mechanism of cinnamaldehyde in A. flavus was investigated via a comparative transcriptomic analysis. The results indicated that twenty five of thirty genes in aflatoxin cluster showed down-regulation by cinnamaldehyde although the cluster regulators aflR and aflS were slightly up-regulated. This may be due to the up-regulation of the oxidative stress-related genes srrA, msnA and atfB being caused by the significant down-reg

SUBMITTER: Wang P 

PROVIDER: S-EPMC6642104 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature