Ex vivo metabolite profiling of paediatric central nervous system tumours reveals prognostic markers.

ABSTRACT: Brain tumours are the most common cause of cancer death in children. Molecular studies have greatly improved our understanding of these tumours but tumour metabolism is underexplored. Metabolites measured in vivo have been reported as prognostic biomarkers of these tumours but analysis of surgically resected tumour tissue allows a more extensive set of metabolites to be measured aiding biomarker discovery and providing validation of in vivo findings. In this study, metabolites were quantified across a range of paediatric brain tumours using ¹H-High-Resolution Magic Angle Spinning nuclear magnetic resonance spectroscopy (HR-MAS) and their prognostic potential investigated. HR-MAS was performed on pre-treatment frozen tumour tissue from a single centre. Univariate and multivariate

SUBMITTER: Bennett CD 

PROVIDER: S-EPMC6642141 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature