The relevance of ANXA5 genetic variants on male fertility.

ABSTRACT:

Purpose

To investigate the effect of the anticoagulation factor annexin A5 on male fertility and to provide perspective on the influence of members of the coagulation cascade on fertility.

Methods

Patients with normozoospermia and with unexplained severe oligozoospermia were retrospectively selected and their genomic DNA sequenced for the promoter region of ANXA5. The genotypes proportions and the odds ratio for carriership of the haplotype M2 were compared between the groups and population control. The clinical data used were gathered from parameters determined during routine clinical assessment and were compared between carriers and non-carriers within the patient groups.

Results

The carrier rates for the haplotype M2/ANXA5 were of 25.73%, 20.81%, and 15.3% in the s

SUBMITTER: Lavorato HL 

PROVIDER: S-EPMC6642233 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature