Ontology highlight
ABSTRACT:
SUBMITTER: Fu R
PROVIDER: S-EPMC6642263 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190719 1
Accumulating evidence indicates that the zinc-finger transcription factor ZEB1 is predominantly expressed in the stroma of several tumours. However, the role of stromal ZEB1 in tumour progression remains unexplored. In this study, while interrogating human databases, we uncover a remarkable decrease in relapse-free survival of breast cancer patients expressing high ZEB1 levels in the stroma. Using a mouse model of breast cancer, we show that ZEB1 inactivation in stromal fibroblasts suppresses tu ...[more]