CircRNA expression profile of bovine placentas in late gestation with aberrant SCNT fetus.

ABSTRACT:

Backgrounds

One of the limitations of somatic cell nuclear transfer (SCNT) strategy to generate genetically modified offspring is the low birth rate. Placental dysfunction is one of the causes of abortion. Circular RNA (circRNA) is noncoding RNA which functions as microRNA (miRNA) sponges in biological processes.

Methods

Two aberrant pregnant placenta (aberrant group, AG) and three normal pregnant placenta (normal group, NG) during late gestation (180-210 days) with bovine SCNT fetus were collected for high-throughput sequencing and analyzed. The host genes of differentially expressed (DE) circRNAs were predicted. And the microRNAs (miRNAs) which could interact with DE circRNAs were analyzed. Then, the expressional level of partial DE circRNAs and corresponding host genes wa

SUBMITTER: Su X 

PROVIDER: S-EPMC6642297 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature