The association between IL-17A and IL-23R polymorphisms and coronary artery disease risk in a Middle Eastern Chinese population.

ABSTRACT:

Background

Polymorphisms in IL-17A and IL-23R may affect the expression of these genes and could contribute to a patient's susceptibility to coronary artery disease (CAD). Although this association was investigated by previous studies, the relationship remains unclear.

Method

We conducted this hospital-based case-control study to determine whether polymorphisms in these two genes could be associated with a risk of CAD. A total of 191 patients and 131 controls, as determined by SXscore, were enrolled in this study. The genotyping was performed with the Sequenom MassARRAY platform.

Results

The results showed that that the FPG and HbA1C levels were higher in patients with CAD than in the controls. In addition, the HDL and ApoA1 levels were significantly higher in the con

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC6642300 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature