MTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis.

ABSTRACT:

Background

Mycobacterium tuberculosis has co-evolved with the human host, adapting to exploit the immune system for persistence and transmission. While immunity to tuberculosis (TB) has been intensively studied in the lung and lymphoid system, little is known about the participation of adipose tissues and non-immune cells in the host-pathogen interaction during this systemic disease.

Methods

C57BL/6J mice were aerosol infected with M. tuberculosis Erdman and presence of the bacteria and the fitness of the white and brown adipose tissues, liver and skeletal muscle were studied compared to uninfected mice.

Findings

M. tuberculosis infection in mice stimulated immune cell infiltration in visceral, and brown adipose tissue. Despite the absence of detectable bacterial diss

SUBMITTER: Martinez N 

PROVIDER: S-EPMC6642333 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature