Dietary vinegar prevents kidney stone recurrence via epigenetic regulations.

ABSTRACT:

Background

Epidemiological evidence of over 9000 people suggests that daily intake of vinegar whose principal bioactive component is acetic acid is associated with a reduced risk of nephrolithiasis. The underlying mechanism, however, remains largely unknown.

Methods

We examined the in vitro and in vivo anti-nephrolithiasis effects of vinegar and acetate. A randomized study was performed to confirm the effects of vinegar in humans.

Findings

We found individuals with daily consumption of vinegar compared to those without have a higher citrate and a lower calcium excretion in urine, two critical molecules for calcium oxalate (CaOx) kidney stone in humans. We observed that oral administration of vinegar or 5% acetate increased citrate and reduced calcium in urinary excret

SUBMITTER: Zhu W 

PROVIDER: S-EPMC6642359 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature