Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasite.

ABSTRACT:

Background

Artesunate the most potent antimalarial is widely used for the treatment of multidrug-resistant malaria. The antimalarial cytotoxicity of artesunate has been mainly attributed to its selective, irreversible and iron- radical-mediated damage of parasite biomolecules. In the present research, iron oxide nanoparticle fortified artesunate was tested in P. falciparum and in an experimental malaria mouse model for enhancement in the selectivity and toxicity of artesunate towards parasite. Artesunate was fortified with nontoxic biocompatible surface modified iron oxide nanoparticle which is specially designed and synthesized for the sustained pH-dependent release of Fe²⁺ within the parasitic food vacuole for enhanced ROS spurt.

Methods

Antimalarial efficacy of

SUBMITTER: Kannan D 

PROVIDER: S-EPMC6642363 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature