Fatty-acid receptor CD36 functions as a hydrogen sulfide-targeted receptor with its Cys333-Cys272 disulfide bond serving as a specific molecular switch to accelerate gastric cancer metastasis.

ABSTRACT:

Background

Hydrogen Sulfide (H₂S), a third member of gasotransmitter family along with nitric oxide (NO) and carbon monoxide (CO), exerts a wide range of cellular and molecular actions in our body. There is a large body of evidence suggesting that H₂S plays an important role in cancer metastasis; however, the molecular mechanisms of H₂S-mediated acceleration of cancer metastasis remain unknown.

Methods

We examined the promote effects of H₂S on phenotype of gastric cancer (GC) cells (including those of express wild type CD36 and mutant CD36) in vitro and in vivo. GC patients' samples were used for clinical translational significance evaluation.

Findings

H₂S triggered lipid metabolism reprogramming by significantly

SUBMITTER: Wang R 

PROVIDER: S-EPMC6642364 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature