Lack of cone mediated retinal function increases susceptibility to form-deprivation myopia in mice.

ABSTRACT: Retinal photoreceptors are important in visual signaling for normal eye growth in animals. We used Gnat2^cplf3/cplf3 (Gnat2^-/-) mice, a genetic mouse model of cone dysfunction to investigate the influence of cone signaling in ocular refractive development and myopia susceptibility in mice. Refractive development under normal visual conditions was measured for Gnat2^-/- and age-matched Gnat2^+/+ mice, every 2 weeks from 4 to 14 weeks of age. Weekly measurements were performed on a separate cohort of mice that underwent monocular form-deprivation (FD) in the right eye from 4 weeks of age using head-mounted diffusers. Refraction, corneal curvature, and ocular biometrics were obtained using photorefraction, keratometry and optical coherence tomography,

SUBMITTER: Chakraborty R 

PROVIDER: S-EPMC6642639 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature