Novel Genetic Locus of Visceral Fat and Systemic Inflammation.

ABSTRACT:

Context

Visceral fat (VF), more than fat elsewhere in the body [mostly subcutaneous fat (SF)], promotes systemic inflammation and related disease. The mechanisms of preferentially visceral accumulation of body fat are largely unknown.

Objective

To identify genetic loci and mechanistic pathways of preferential accumulation of VF and associated low-grade systemic inflammation.

Design

Genome-wide association study (GWAS).

Setting and participants

Population-based cohort of 1586 adolescents (aged 12 to 19 years) and adults (aged 36 to 65 years).

Main outcome measures

Abdominal VF and SF were measured with MRI, total body fat (TBF) was assessed with bioimpedance, and low-grade systemic inflammation was examined by serum C-reactive protein (CRP) measurement.

SUBMITTER: Shin J 

PROVIDER: S-EPMC6642667 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature