Ontology highlight
ABSTRACT:
SUBMITTER: Scharer CD
PROVIDER: S-EPMC6642679 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nature immunology 20190701 8
Systemic lupus erythematosus (SLE) is characterized by the expansion of extrafollicular pathogenic B cells derived from newly activated naive cells. Although these cells express distinct markers, their epigenetic architecture and how it contributes to SLE remain poorly understood. To address this, we determined the DNA methylomes, chromatin accessibility profiles and transcriptomes from five human B cell subsets, including a newly defined effector B cell subset, from subjects with SLE and health ...[more]