Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus.

ABSTRACT: Type III interferon (IFN-λ) is important for innate immune protection at mucosal surfaces and has therapeutic benefit against influenza A virus (IAV) infection. However, the mechanisms by which IFN-λ programs adaptive immune protection against IAV are undefined. Here we found that IFN-λ signaling in dendritic cell (DC) populations was critical for the development of protective IAV-specific CD8⁺ T cell responses. Mice lacking the IFN-λ receptor (Ifnlr1^-/-) had blunted CD8⁺ T cell responses relative to wild type and exhibited reduced survival after heterosubtypic IAV re-challenge. Analysis of DCs revealed IFN-λ signaling directed the migration and function of CD103⁺ DCs for development of optimal antiviral CD8⁺ T cell responses, and bioi

SUBMITTER: Hemann EA 

PROVIDER: S-EPMC6642690 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature