Altered differentiation is central to HIV-specific CD4⁺ T cell dysfunction in progressive disease.

ABSTRACT: Dysfunction of virus-specific CD4⁺ T cells in chronic human infections is poorly understood. We performed genome-wide transcriptional analyses and functional assays of CD4⁺ T cells specific for human immunodeficiency virus (HIV) from HIV-infected people before and after initiation of antiretroviral therapy (ART). A follicular helper T cell (T_FH cell)-like profile characterized HIV-specific CD4⁺ T cells in viremic infection. HIV-specific CD4⁺ T cells from people spontaneously controlling the virus (elite controllers) robustly expressed genes associated with the T_H1, T_H17 and T_H22 subsets of helper T cells. Viral suppression by ART resulted in a distinct transcriptional landscape, with a reduction in the

SUBMITTER: Morou A 

PROVIDER: S-EPMC6642691 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature