Associations between vascular risk factors and brain MRI indices in UK Biobank.

ABSTRACT:

Aims

Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between multiple vascular risk factors (VRFs) and detailed aspects of brain macrostructure and microstructure in large community-dwelling populations across middle and older age.

Methods and results

Associations between VRFs (smoking, hypertension, pulse pressure, diabetes, hypercholesterolaemia, body mass index, and waist-hip ratio) and brain structural and diffusion MRI markers were examined in UK Biobank (N = 9722, age range 44-79 years). A larger number of VRFs was associated with greater brain atrophy, lower grey matter volume, and poorer white matter health. Effect sizes were small (brain structural R2 ≤1.8%). Higher aggregate vascular

SUBMITTER: Cox SR 

PROVIDER: S-EPMC6642726 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature