Less dementia and stroke in low-risk patients with atrial fibrillation taking oral anticoagulation.

ABSTRACT:

Aims

To investigate if patients with atrial fibrillation (AF) without clear indication for oral anticoagulant (OAC) due to perceived low stroke risk may benefit from OAC treatment when also dementia and intracerebral bleeding risks are considered.

Methods and results

Retrospective study of cross-matched national registries of all individuals in Sweden with a hospital diagnosis of AF between 2006 and 2014 (n = 456 960). Exclusion was made of patients with a baseline CHA2DS2-VASc score >1, not counting female sex, and of patients with previous diagnosis of dementia or intracranial bleeding. After exclusions, 91 254 patients remained in the study of whom 43% used OAC at baseline. Propensity score matching and falsification endpoints were used. Treatment with OAC was associated

SUBMITTER: Friberg L 

PROVIDER: S-EPMC6642728 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature