Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.

ABSTRACT: The incidence of melanoma is increasing, particularly in young women, and the disease remains incurable for many because of its aggressive, metastatic nature and its high rate of resistance to conventional, targeted, and immunological agents. Cathepsins are proteases that are critical for melanoma progression and therapeutic resistance. Intracellular cathepsins cleave or degrade proteins that restrict cancer progression, whereas extracellular cathepsins directly cleave the extracellular matrix and activate proinvasive proteases in the tumor microenvironment. Cathepsin secretion is markedly increased in cancer cells. We investigated the signaling pathways leading to increased cathepsin secretion in melanoma cells. We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted

SUBMITTER: Tripathi R 

PROVIDER: S-EPMC6642731 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature