Early signatures of bleeding and mortality in patients on left ventricular assist device support: novel methods for personalized risk-stratification.

ABSTRACT: Background: Left ventricular assist devices (LVADs) provide support for patients with end-stage heart failure. The aims of this study were to determine whether baseline analysis and early trends in routine laboratory data, platelet activity, and thromboinflammatory biomarkers following LVAD implantation reveal trends that predict personalized risks of one-year gastrointestinal (GI) bleeding, stroke, pump thrombosis, drive-line infections and mortality in patients on LVAD support. Methods: We performed an observational study at the University of Kentucky with 61 participants who underwent first-time LVAD implantation. Blood was collected at baseline and post-op days 0, 1, 3 and 6 as well as clinical follow-up. Demographics, clinical characteristics, one-year adverse events and

SUBMITTER: Shrout T 

PROVIDER: S-EPMC6642809 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature