Efavirenz pharmacokinetics during pregnancy and infant washout.

ABSTRACT:

Background

Limited data exist on efavirenz pharmacokinetics in HIV-positive pregnant women and neonatal washout.

Methods

HIV-infected pregnant women receiving 600 mg efavirenz once daily had intensive steady-state 24-h pharmacokinetics profiles during the second trimester (2T), third trimester (3T) and 6-12 weeks postpartum (PP). Maternal and umbilical cord blood samples were drawn at delivery and neonatal washout pharmacokinetics were determined. Therapeutic targets were the estimated 10th percentile efavirenz area under the concentration-time curve (AUC) in non-pregnant historical controls (40.0 μg•h/ml) and a trough concentration (C_{24 h}) of 1 μg/ml. Data were prospectively collected within two trials: IMPAACT P1026s (United States) and PANNA (Europe).

Result

SUBMITTER: Kreitchmann R 

PROVIDER: S-EPMC6642905 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature