HIV pre-exposure prophylaxis for adolescent girls and young women in Africa: from efficacy trials to delivery.

ABSTRACT:

Introduction

Adolescent girls and young women (AGYW) in Africa have high HIV incidence despite scale-up of HIV testing and HIV treatment. Placebo-controlled trials of tenofovir-based pre-exposure prophylaxi (PrEP) in diverse populations demonstrated that PrEP works with close to 100% effectiveness if taken with high, but not perfect, adherence. Divergent efficacy estimates among African AGYW led to demonstration and implementation projects to better understand motivations for HIV prevention, uptake, adherence and persistence to PrEP. To inform PrEP programmes, the design and initial findings from PrEP demonstration projects for AGYW are reviewed.

Discussion

Early lessons from PrEP implementation projects among young African women include: (1) awareness and demand creation wi

SUBMITTER: Celum CL 

PROVIDER: S-EPMC6643076 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature