Low serum IGF1 is associated with hypertension and predicts early cardiovascular events in women with rheumatoid arthritis.

ABSTRACT:

Objectives

Since low insulin-like growth factor (IGF) 1 is often linked to inflammation, we analyze whether serum levels of IGF1 are associated with cardiovascular disease (CVD) in rheumatoid arthritis (RA) in a longitudinal observational study.

Methods

A CVD risk was estimated (eCVR) in 184 female RA patients (mean age 52 years) and in 132 female patients after ischemic stroke (mean age 56 years) with no rheumatic disease, using the Framingham algorithm. The median level of IGF1 divided the cohorts in IGF1^high and IGF1^low groups. A 5-year prospective follow-up for new CVD events was completed in all RA patients. The Mantel-Cox analysis and event-free survival curves were prepared. Unsupervised clustering of proteins within the IGF1 signaling pathway wa

SUBMITTER: Erlandsson MC 

PROVIDER: S-EPMC6643304 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature