Insights into the ZIKV NS1 Virology from Different Strains through a Fine Analysis of Physicochemical Properties.

ABSTRACT: The flavivirus genus has several organisms responsible for generating various diseases in humans. Recently, especially in tropical regions, Zika virus (ZIKV) has raised great health concerns due to the high number of cases affecting the area during the last years that has been accompanied by a rise in the cases of the Guillain-Barré syndrome and fetal and neonatal microcephaly. Diagnosis is still difficult since the clinical symptoms between ZIKV and other flaviviruses (e.g., dengue and yellow fever) are highly similar. The understanding of their common physicochemical properties that are pH-dependent and biomolecular interaction features and their differences sheds light on the relation strain-virulence and might suggest alternative strategies toward differential serological diagno

SUBMITTER: Poveda-Cuevas SA 

PROVIDER: S-EPMC6643396 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature