Influence of Hydrogen-Bonding Additives on Electrospinning of Cyclodextrin Nanofibers.

ABSTRACT: The electrospinning of highly concentrated solutions of cyclodextrin (CD) leads to bead-free nanofibers without the need of a polymeric carrier. The occurrence of numerous hydrogen bonds among CD molecules is the main driving force for their electrospinning, and hence, additives with hydrogen-bonding potential can disturb the aggregation of CD molecules and affect their electrospinning. In this study, we systematically investigated the influence of five different hydrogen-bonding additives, i.e., methylamine (MA), ethylenediamine (ED), urea, 2,2,2-trifluoroethanol (TFE), and 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), on the solution behavior of hydroxypropyl-β-CD (HP-β-CD) by rheology, conductivity, and NMR analyses, and the morphology of the electrospun HP-β-CD nanofibers by scanning elect

SUBMITTER: Topuz F 

PROVIDER: S-EPMC6643398 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature