Pencil and Paper Estimation of Hansen Solubility Parameters.

ABSTRACT: Simple procedures to estimate Hansen solubility parameter (HSP) components from structural formulas are investigated. The best results are obtained using a simple relationship with molar volume and refractivity for the dispersion component, and using additivity models based on tailored fragments specifically designed for the polar and hydrogen bonding components. Despite large errors for some classes of chemicals, including small inorganic molecules, ionic liquids, and high halogen compounds, these models yield average absolute deviations from reference on par with state-of-the-art models and lower than reported using molecular dynamics simulations or nonlinear quantitative structure-property relationship models based on a limited set of quantum chemical descriptors. In contrast to group c

SUBMITTER: Mathieu D 

PROVIDER: S-EPMC6643659 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature