Postmenopausal Fracture History and Survival After Reproductive Cancer Diagnosis.

ABSTRACT:

Background

Postmenopausal bone fracture's have been proposed as a marker of lifetime estrogen exposure and have been associated with decreased risk of breast and endometrial cancer. It is plausible that prediagnostic fractures may be related to survival of estrogen-sensitive cancers.

Methods

We evaluated a cohort of breast (n = 6411), endometrial (n = 1127), and ovarian (n = 658) cancer cases diagnosed between 1992 and 2010 while participating in the Women's Health Initiative. Postmenopausal fracture history was assessed from baseline reports of fractures after age 55 years and incident fractures that occurred at least one year prior to cancer diagnosis during study follow-up. Using Cox regression, we compared women with and without a history of fractures with respect to ove

SUBMITTER: Newcomb PA 

PROVIDER: S-EPMC6643753 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature