Hydroxylamine Derivatives as a New Paradigm in the Search of Antibacterial Agents.

ABSTRACT: Serious infections caused by bacteria that are resistant to commonly used antibiotics have become a major global healthcare problem in the 21st century. Multidrug-resistant bacteria causing severe infections mainly grow in complex bacterial communities known as biofilms, in which bacterial resistance to antibacterial agents and to the host immune system is strengthened. As drug resistance is becoming a threatening problem, it is necessary to develop new antimicrobial agents with novel mechanisms of action. Here, we designed and synthesized a small library of N-substituted hydroxylamine (N-HA) compounds with antibacterial activity. These compounds, acting as radical scavengers, inhibit the bacterial ribonucleotide reductase (RNR) enzyme. RNR enzyme is essential for bacterial prolifer

SUBMITTER: Miret-Casals L 

PROVIDER: S-EPMC6643834 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature