P2Y₂ R deletion ameliorates sialadenitis in IL-14α-transgenic mice.

ABSTRACT:

Objective

Interleukin-14α-transgenic (IL-14αTG) mice develop an autoimmune exocrinopathy with characteristics similar to Sjögren's syndrome, including sialadenitis and hyposalivation. The P2Y₂ receptor (P2Y₂ R) for extracellular ATP and UTP is upregulated during salivary gland inflammation (i.e., sialadenitis) where it regulates numerous inflammatory responses. This study investigated the role of P2Y₂ Rs in autoimmune sialadenitis in the IL-14αTG mouse model of Sjögren's syndrome.

Materials and methods

IL-14αTG mice were bred with P2Y₂ R^-/- mice to generate IL-14αTG × P2Y₂ R^-/- mice. P2Y₂ R expression, lymphocytic focus scores, B- and T-cell accumulation, and lymphotoxin-α expression were

SUBMITTER: Woods LT 

PROVIDER: S-EPMC6644053 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature